Multimodal Analyses of Stable Vitiligo Skin Identify Tissue Interactions That Control Disease Persistence
Abstract Take Home Message
Stress keratinocytes exhibit a unique signature – metabolic preferences for oxidative phosphorylation, expression of stress keratins, alarmins and CXCL9/10 and diminished WNT signaling – and likely drive the persistence of white patches in vitiligo. They may be targeted for therapy in the future.
Lihua Zhang, Griffin Lentsch , Jessica L Flesher, Suoqin Jin, Christopher Polleys, Seong Jin Jo, Craig Mizzoni, Pezhman Mobasher, Jasmine Kwan, Francisca Ruis-Diaz, Bruce J Tromberg, Irene Georgakoudi, Qing Nie, Mihaela Balu, Anand K Ganesan
No relevant disclosures.