Impaired IFN-γ-induced PD-L1 Expression on Human Vitiligo Melanocytes
Summary
The lack of PD-L1 upregulation by melanocytes in the presence of IFN-γ-producing T cells shows that melanocytes do not confer protection against T cell attack during vitiligo pathogenesis. Manipulating PD-1/PD-L1 signaling, therefore, may be a therapeutic option for human vitiligo.
Additional Authors
Gabrielle Krebbers, Esther P.M. Tjin, Karin J. Willemsen, Alesha Louis, Veronique A.L. Konijn, Vidhya S. Narayan, Nicoline F. Post, Walbert J. Bakker, Cornelis J.M. Melief, Marcel W. Bekkenk, Rosalie M. Luiten